Preparation and Characterization of the Silk Fibroin 3D Scaffolds with Porous and Interconnected Structure

Authors

  • Jun Song Soochow University, Renai Road, Suzhou, Jiangsu 215123, China
  • Xiaoqin Wang Soochow University, Renai Road, Suzhou, Jiangsu 215123, China
  • Jiashen Li School of Materials, The University of Manchester, Manchester, M13 9PL, UK

DOI:

https://doi.org/10.3993/jfbim00288

Keywords:

Silk fibroin;Paraffin spheres;Tissue engineering;Porous scaffold.

Abstract

Silk fibroin (SF) is wildly used in the field of biomedical science. Considering the contradiction between suitable pore size and outstanding mechanical properties, this research focused on the topic of preparing the 3D scaffolds with large pore sizes and high interconnectivity. For preparing the silk fibroin 3D scaffold samples, three kinds of porogens were applied in two methods which paraffin spheres were used in freezedrying. Sodium chloride (NaCl) and sodium carbonate (Na2CO3) were used in leaching respectively. Different pore size of porogens were used to control the pore size and porosities of prepared scaffold samples. Some basic properties of scaffold samples were characterized including surface morphology, chemical structure, porosity and mechanical performance. The best porosity of sample reached to 93% in the research.

Published

2019-02-04

Issue

Section

Articles