Effects of sleep deprivation on brain functional network

Abstract

1College of Electronic and information Engineering, Southwest University, China 2School of Computer and Information Science, Southwest University, Chongqing, China (Received September 09 2018, accepted November 22 2018) Abstract Sleep deprivation adversely affects the brain and cognitive function. Few studies have analyzed effect of the \u00a0sleep \u00a0deprivation \u00a0and \u00a0partial \u00a0sleep \u00a0restriction \u00a0on \u00a0rest-state \u00a0brain \u00a0functional \u00a0network. \u00a0In \u00a0this \u00a0study, \u00a0we investigated the changes of rest-state functional magnetic resonance imaging (fMRI) in topological architectures of brain functional networks in sleep deprivation among 36 samples in sleep deprivation and 40 normal sleep controls. Our analysis revealed that the brain functional network of the clustering coefficient, characteristic path length \u00a0and local \u00a0efficiency \u00a0are \u00a0significantly \u00a0increased \u00a0but \u00a0the \u00a0global \u00a0efficiency \u00a0decreased \u00a0significantly \u00a0in \u00a0sleep \u00a0deprivation. Additionally, \u00a0significant \u00a0alterations \u00a0in \u00a0nodal \u00a0efficiency \u00a0were \u00a0also \u00a0found \u00a0in \u00a0sleep \u00a0deprivation, \u00a0involving \u00a0anterior cingulate, inferior parietal, supramarginal gyrus, caudate nucleus, thalamus are significant decreased, and themiddle temporal gyrus are significant increased.Our results suggested that the groups of sleep deprivation were associated with disruptions in the topological structure of brain functional networks.